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KMID : 1140120130180010048
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Cancer Prevention Research
2013 Volume.18 No. 1 p.48 ~ p.54
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Anthocyanins from the Fruit of Vitis coignetiae Pulliat Have Anti-cancer Properties by Inhibiting in Cancer Proliferation, Invasion, Adhesion, and Angiogenesis in Breast Cancer Cells
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Kim Min-Jeong
Lee Won-Sup
Yun Jeong-Won
Lu Jing-Nan
Jung Ji-Hyun
Lee Sang-Min
Kim Seok-Hyun
Kim Hye-Jung
Lee Jeong-Hee
Jung Woon-Tae
Choi Yung-Hyun
Kim Gon-Sup
Jung Jin-Myung
Ryu Chung-Ho
Shin Sung-Chul
Hong Soon-Chan
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Abstract
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Vitis coignetiae Pulliat (Meoru in Korea) has been used as a remedy for inflammatory diseases and various cancers. Although a previous study have shown that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) have anti-NF-?B activities. It is still not known whether AIMs suppress NF-?B-regulated molecules in breast cancer cells. This study was to determine the molecules involved in AIM-induced anticancer effects especially focusing on cancer metastasis. We found that AIMs suppressed cancer cell proliferation, migration and invasion. This also suppressed the NF-?B-regulated proteins involved in caner proliferation, invasion, adhesion and angiogenesis. In conclusion, this study demonstrates that the anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit the NF-?B downstream molecules involved in caner proliferation, invasion, adhesion and angiogenesis, implying that AIMs have anti- metastatic properties.
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KEYWORD
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Anthocyanins, Vitis coignetiae Pulliat, Proliferation, Invasion, Adhesion, Breast cancer
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